70 Replies to “Can Antidepressants Stop Working?

  1. Thank you for posting this, I've been wondering about this interaction with my sertraline and it feels great to be educated!

  2. I was on 27 pills a day…high BP… and severely over weight. I had 13 major surgeries that took 5 organs… stroke.. severe stomach problem. Today…on NO pills! Lost over 40lbs.. walk over seven miles a week.. and i feel great!! What did I do? I stopped listening to Drs!! Got off the pills and as of now i haven't seen a Dr in 4 years 😊. Stop listening to pill pushers!! Drs are the exact same thing as a drug dealer in the local bar. I actually feel like I did when i was in my 20s and I'll only go to the er if i have an accident..i will no longer be listening to Drs… they lie!!!!

  3. Thanks for another great video. Prozac Poop Out! Sooo funny! It's even funnier because you said it with a straight face. :)))
    I tried Prozac and it gave me BLINDING headaches. I heard Prozac isn't prescribed much anymore because it gave a lot of people migraines. Is that true?

  4. Thanks for this information. Your videos are always well produced and accessible.

    You suggested bringing medication conflicts to your doctor’s attention. Should you stay with a doctor who did not notice a conflict with your medication? I don’t think I should have to notice conflicts and advise my doctor. I’ve had a doctor mess up my prescriptions. He’s at the top of his field as a specialist; however, he can be sloppy, careless, uncommunicative and unprofessional.

  5. So many variables. That in itself is depressing! Thanks for laying it all out for us, Dr Mark's. Knowledge is power! – dj

  6. If I could request a topic for the new video I would like to know how bad the consequences are for a person who is schizophrenic or has schizoaffective disoder like I do to go withdraw from their antipsychotic medication

  7. Excellent information. I LOVE that you mentioned diet and how it can effect your moods. We are living in a nation that eats food-like substances and expect our brains to function normally. You can't supplement yourself into health! Eat the food!! Real food, as it comes out of the ground! I have bipolar disorder and learned from a good friend, that wrote a book about using nutrition to combat mental illness, that nutrition matters. I do like QSciences supplement for when I am going through a bad spell with the bipolar. But, it loses its effectiveness if I take it all the time. The real challenge is to remember to start it before I decend into what I call the outer darkness…LOL Gotta laugh about it, crying doesn't help! Thanks again.

  8. Great video, thank you.

    Speaking of MAOI’s, can you give your opinion on them? I was on Nardil and it took away all of my depression and anxiety, but within a month, everything went back to normal.

    What is your opinion on Tranylcypromine? How does it compare to amphetamine, or if it does at all? Does it work on dopamine?

    Thank you! Love your videos.

  9. I take drugs holiday to reduce tolerance, also tricyclic antidepressants work fine and no tolerance but the side effects is not worth it

  10. Loved this new video Dr. as always! I have bipolar disorder and I couldn’t stop wondering if this is the same for bipolar disorder medications, aka, mood stabilizers such as Lithium and Quetiapine. Would love to hear your thoughts about this. Great week!

  11. Thank you dr. Tracey
    I have 2 questions please,
    Can treatment resistant depression happen to bipolar patients? Even when given for example Lamictal?

    Are there SSRIs or antidepressants considered contraindicated for bipolar patients? Even when given with a mood stabilizer?

  12. Doc I'm taking Cymbalta 60mg BID here recently I've noticed if I don't take my Cymbalta everyday that's a I take it today and tomorrow I don't take it right away I noticed there's a changing me did I go a little bit further down but if I take it as soon as I feel that I go back to feeling a little bit better it's just possible to happen like this? I've been taking Cymbalta since it came out on the market of course I'm taking the generic now. 1 other question. Why don't all ADHD medications work the same ? For an example I started out back in 2006 taking Ritalin that didn't work so the psychiatrist I was seeing it put me on Compazine and that medication didn't work either so he put me on Strattera but that medication didn't work either so I tried Adderall and that medication worked ADHD medicines work the same? I will say this about the pain medication it has no effect on whether I feel any better with my Bipolar. And I got one more question for you doc can diazepam stop seizures? Because 2016 I had emergency room in Madison Wisconsin tell me that diazepam stop seizures but in May 2019 a neurologist said that that has a pain can cause seizures why would he tell me that when two other medical professions told me the opposite? I greatly appreciate you answering these questions I would like to send me an email with the answers let me know and I will give you my email address.

  13. Thank god i reduced my dosage now….I skip antidepressant now day by day and felt normal but did not completely stop…

  14. I am fairly confident that I had this issue with the medication called Effexor. I was using it from 2017 until March 2018 and it worked really well at the beginning but slowly started to increase my symptoms back to how they were before taking it. Now I am at a point where I do not even need to take medication 🙂 Effexor was my last one.

  15. Psychiatrists are not scientists … some are not even doctors … since no one understands what SSRI do or how they do it how can they possibly explain why the same drugs are no longer exhibiting the same response?? About 50% of patients improve without drugs if given the opportunity why could it not be that something else changed unrelated to the drugs ?? Psychiatry is built on a belief system based on accepting whatever the Pharmacy reps and pill pushers tell you … if the psychiatrist can't baffle you with brilliance they just befuddled you with bull excrement …. the truth is SSRI drugs do not treat your problem at all … these drugs create a new problem that may mask your current brain illness until it goes away or increases. SSRI drugs are not a cure so much as a competing illness created by the drug. It's like trying to right a listing ship which is taking on water through a hull breach by flooding other compartments. Initially the ship is righted but then the breach is repaired and the ship is permanently at a disadvantage because it is carrying half a cargo capacity of water. Perhaps the breach is repaired ( your brain can repair itself or recover ) and the leaking compartments are pumped out … now the drug flooded compartments are causing the ship to list in another direction ( need to stop the drugs not add more ). Another possibility is the breach continues to add ballast in the affected compartments so the treatment is to add more ballast in the unaffected compartments which can lead to the ship performing a more balanced sinking. Psychiatric drugs are not curative and they do not balance out brain chemistry … the cure these drugs offer is as bad as the problem … it's like putting a cast on a broken arm and just leaving the cast on forever because you might break your arm again … despite the fact that with the cast you lose 50% of the function in that arm

  16. Different brands of medication can make a difference. I take tramadol for pain and I've notice that some brands have a more stimulating effect while others a more calming effect. So now I keep the different brands for different points in the day, ie I dont use the more wakefulness brand at night.

  17. Great video. Very interesting and informative. Thank you so much Dr. Marks. I'm using Lyrica (pregabalin) for chronic pain for already about 5 years. I did take recently a medication holiday and stopped for about a few weeks in using this medicine. So when I started after that holiday again with this medicine it really does work much better again. I'm having less pains now. I think the brain gets a time out and can 'reset' again. It's like, when your computer is working slower after a time, you use a program to scan the PC well and after that it works faster again.
    So I think it's true, that my brain first got used to the medication and it didn't work not so well anymore after using it for 5 years.
    I like to do this medicine holiday time more often in the future.

    My question to you Dr. Marks is do you have any idea what might be a good time to take such a holiday? After one year maybe or so?
    Thanks again for this professional video. I have learned a lot I didn't know of. You explained it all very good doctor Tracey.
    Greetings from Ben in the Netherlands 😃🇳🇱

  18. Pls make a video about selfharm.thanks🌹
    And how to know what i feel its the effect of meds or my high or low of bpd or its normal. im confiuse about my feeling are heathly or not

  19. Thanks as always, Doctor. I was on a minimum dose of escitalopram for several years, and it mostly worked, but when I recently discussed my situation with my own doctor, he simply doubled the dose. Voila!

  20. Isn't this the story of life generally speaking? When it comes to drugs, you can have your dose upped to a more effective level, but what about people. If you get sick of your wife, it's not like you can get 5 extra milligrams of wife. We constantly quit jobs, move to new cities, and get divorced because maybe the magical things we were taught to think of as inexhausatable are not all that different from drugs. How many times can you ride a rollercoaster until you are scrolling through your phone upside down? Is completing each other's sentences true love, or is that an expiration date?

  21. I don't have 'episodes'. My depression never leaves. I'm in bed all day. Sad everyday. I've been on over 30 medication. Nothing works, or works 20% like ssri, or side effects too hard like snri.

  22. I’m going to do all of your tips. I need all the help I can get. It seems I’m fine for the first few months then everything comes back again.

  23. Can you do a video on building tolerance to adhd meds (mostly stimulants) I've been on vyvanse for nearly a year after taking a couple years off meds (having taken ritalin and concerta in school but getting nasty side effects). The vyvanse worked amazingly to start with but i think ive developed a tolerance because ive noticed myself falling into older less healthy patterns and becoming less focused

  24. I love your videos and find them really helpful! I was wandering if you could do a video on forming a relationship/friendship and supporting someone with ptsd. I recently met someone who has severe ptsd from a previous abusive relationship (physical and mental) but we had to break it off because it got too much for her when she found out I had feelings for her. She is terrified of men and finds it hard establishing trust. She also suffers anxiety, depression, derealisation and has seizures. I would really like her to be apart of my life, even if it's just a friendship. How do I prove myself to her? I also suffer from severe anxiety which hasn't helped. Thankyou for any advice/help 🤗

  25. Thank you for posting, mine stopped working awhile ago,I'm having trouble finding the right one but I hope to get the right one soon. God bless.

  26. I have been diagnosed as bipolar disorder type 2 rapid cycling also i take wellbutrin for about 3 months or maybe even more now i am developing tolerance or lower reaction to it, i take one tablet every day once i mean, should i take it twice or what? knowing that my psychiatrist prescription at first was twice daily and he decreased it because it induced hypomania

  27. I had reverse tolerance to parnate I took it for two months and had to stop my depression was better but side effects were severe this was back in 1981

  28. Great video. I'm schizophrenic and worry one day I might develop a tolerance to anti psychotic drugs. What is the percent of people with schizophrenia develop a tolerance to their medication, if any? ….Thanks

  29. @ Dr. Marks.. How are you happy Wednesday.. ' I was amazed about with video this was a excellent breakdown it's so well needed as always . YOU deliver wonderful presentation of diagnosis about how the body works with medications ) will share video with family & friend's as all ways .) Thank you again stay bless🙏

  30. Good day Doctor. Tracey! I was just wondering, what if a psychiatrist develops depression, anxiety, PTSD or any other mental illnesses, can they prescribe themselves their own medications or can they treat their own selves? Psychiatrists are human beings after all. It is possible that they can also experience mental illness themselves…

  31. do you advise or endorse the use of hemp supplements by any of your clients for the possibilities of mood elevation doctor ?

  32. i am on zoloft for anxiety. i stayed 5 weeks at 100 mb and 6 weeks at 75 mg, instead of getting less anxious i get agitated, ringing in the ears, eyelid twiching, muscle spams and tiredness, it seems that either the dose is too much or this drug is not for me. while i was feeling better in 50 mg before reaching the 100 mg the doc prescribed, u think that my dose is too much or too low ? i will ask the doc to go down to 50 mg or find a more relaxing med. i also take lyrica 75 mg x 3 and it doesnt do much, what do u think doc ?

  33. I've been on Paxil for about 28 years. I don't feel like it's working anymore & maybe I should have it changed. Thank you for the great info!

  34. I suffer from Anxiety Disorder. I have been prescribed prozac 20mg and etizolam 0.5 mg twice a day(short term)… but i am too scared to take them. However my anxiety is making my life more miserable day by day….what shud i do ?

  35. I was on Effexor and had the worst depression I ever had while still taking the medication. I wonder if it was tolerance or just that the medication wasn't working for me. I was on Effexor for almost two years.

  36. Tracey love to know… How do u know when lexpro had a bad reaction in person from first dose… As first time i took it 5mg dropped stuff and had like overstimulation had to cover eyes…… Question is antidepressants how we know normal response to first dose or when to say check with doctor..

  37. I am a proud vegan of seven years. My plant based vegan diet has improved my mood, contributed to weight loss from antipsychotic medication, and reversed my acne and irritable bowel syndrome. Can Seroquel cause or trigger IBS?

  38. Hi Dr Tracey,
    I have ADHD, Bipolar disorder 2 and Aspergers syndrome and have been taking only dexamphetamine sulfate (5mg 6x tablets a day) on and off for about 5 years now (last 3 years more consistent except when I was pregnant twice in that time). I've found that overtime especially after giving birth to my second child, I've built immunity to the drug. It still does it's job during the first few hours after taking it but the effects don't last as long as they used to. I've tried to take the dosages differently to see if that helps but they're still not as effective as they were when I started them. They still give me the initial effect so I rely on them to start my day but I was wondering if this is due to the fact that I've built so much immunity to them or is there another underlying issue. I was diagnosed as having post natal depression as well however all the antidepressants and anti psychotics I was prescribed made me so Ill I was confined to my bed for a week which is not practical for a mother caring for 2 babies. Any advice would help.
    Thank you.

  39. Thanks for this video! Could you do a video on sleep issues in bipolar and how it differs to those without. Insomnia, hypersomnia, trouble waking up and delayed sleep onset disorder long term treatment. What medications can exacerbate those with both sleep apnea and insomnia. Does a normal psychiatrist tackle bipolar sleep irregularities or sleep psychiatrist?

  40. I was taking lexapro for alittle then I stopped and now i'm on it again and it still works but not as well.. anyone else have this problem?

  41. I have a question, lithium destroyed my thyroid and I got taken off it, however lithium is the only thing that really helped me, antipsychotics gave me metabolic syndrome and I was told I cannot handle them. I've tried other mood stabilizers and am on lamictal 200mg but it isn't as effective for my mania or mixed episodes. I know that lithium can continue to affect my body and affect my kidneys, is it possible that I can go ahead and continue it despite this and take the risk? I would rather face renal failure or death and have a few more years of "stable" life that is healthy than more years that will instead be of poor quality and disastrous mood instability.

  42. This has happened to me with every psych medication I've ever taken. Every single one that has helped (of which there have been few) has stopped working. It's heartbreaking.

  43. Hi Dr. Marx,
    I am currently working toward my LPC, and I was wondering if it is possible to have multiple mental disorders? I have seen some patients be diagnosed with as many as 4 disorders? In my coursework, I recall learning this is not possible, but in my professional work I’m being told the opposite. Some clarification regarding this conflicting information would be very helpful, thanks!

  44. Love that you now say the generic drug name and after the brand name, specially for us not in USA, in previous videos I had to Google a lot to see what drug you were referring to.
    Keep with your amazing work!

  45. Thank you Dr Mark this episode is very informative.
    The question is can antidepressants treat PDD as any depression or have different pills?

  46. I would like to know why some people are overly sensitive to antidepressants. I've tried many different medications and always get bad side effects and can't go on eith the medication.

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