How in vitro fertilization (IVF) works – Nassim Assefi and Brian A. Levine


In 1978, Louise Brown became the world’s first baby to be born
by in vitro fertilization, or IVF. Her birth revolutionized
the field of reproductive medicine. Given that approximately one in eight
heterosexual couples has difficulty conceiving, and that homosexual couples
and single parents often need clinical help to make a baby, the demand for IVF has been growing. IVF is so common, that more than 5 million
babies have been born through this technology. IVF works by mimicking the brilliant
design of sexual reproduction. In order to understand IVF, we first need to take a look
at the natural process of baby making. Believe it or not,
it all starts in the brain. Roughly fifteen days
before fertilization can happen, the anterior pituitary gland secretes
follicle stimulating hormone, FSH, which ripens a handful
of follicles of the ovary that then release estrogen. Each follicle contains one egg, and on average,
only one follicle becomes fully mature. As it grows and continues
to release estrogen, this hormone not only helps coordinate
growth and preparation of the uterus, it also communicates to the brain
how well the follicle is developing. When the estrogen level is high enough, the anterior pituitary releases a surge
of luteinizing hormone, LH, which triggers ovulation and causes the follicle to rupture
and release the egg. Once the egg leaves the ovary, it is directed into the Fallopian tube
by the finger-like fimbriae. If the egg is not fertilized
by sperm within 24 hours, the unfertilized egg will die, and the entire system will reset itself, preparing to create a new egg
and uterine lining the following month. The egg is the largest cell in the body and is protected by a thick,
extracellular shell of sugar and protein called the zona pellucida. The zona thwarts the entry and fusion
of more than one sperm, the smallest cell in the body. It takes a man two to three months
to make sperm, and the process constantly renews. Each ejaculation during sexual intercourse
releases more than 100 million sperm. But only 100 or so will ultimately
make it to the proximity of the egg, and only one will successfully penetrate
through the armor of the zona pellucida. Upon successful fertilization, the zygote immediately begins
developing into an embryo, and takes about three days
to reach the uterus. There, it requires
another three or so days to implant firmly into the endometrium,
the inner lining of the uterus. Once implanted, the cells that
are to become the placenta secrete a hormone that signals
to the ovulated follicle that there is a pregnancy in the uterus. This helps rescue that follicle,
now called the corpus luteum, from degenerating as it normally would
do in that stage of the menstrual cycle. The corpus luteum is responsible
for producing the progesterone required to maintain the pregnancy
until six to seven weeks of gestation, when the placenta develops
and takes over, until the baby is born
approximately 40 weeks later. Now, how do you make a baby in a lab? In patients undergoing IVF, FSH is administered at levels
that are higher than naturally occuring to cause a controlled
overstimulation of the ovaries so that they ultimately
produce multiple eggs. The eggs are then retrieved
just before ovulation would occur, while the woman is under anesthesia, through an aspirating needle
that is guided by ultrasound. Most sperm samples are produced
by masturbation. In the laboratory, the identified eggs
are stripped of surrounding cells and prepared for fertilization
in a petri dish. Fertilization can occur
by one of two techniques. In the first, the eggs are incubated
with thousands of sperm and fertilization occurs naturally
over a few hours. The second technique maximizes
certainty of fertilization by using a needle
to place a single sperm inside the egg. This is particularly useful when there is
a problem with the quality of the sperm. After fertilization, embryos can be
further screened for genetic suitability, frozen for later attempted pregnancies, or delivered into the woman’s uterus
via catheter. Common convention is to transfer
the embryo three days after fertilization, when the embryo has eight cells, or on day five, when
the embryo is called a blastocyst, and has hundreds of cells. If the woman’s eggs are of poor quality
due to age or toxic exposures, or have been removed due to cancer, donor eggs may be used. In the case that the intended mother
has a problematic uterus, or lacks one, another woman, called
the gestational carrier or surrogate, can use her uterus to carry the pregnancy. To increase the odds of success, which are as high as 40%
for a woman younger than 35, doctors sometimes transfer
multiple embryos at once, which is why IVF results
in twins and triplets more often than natural pregnancies. However, most clinics seek to minimize
the chances of multiple pregnancies, as they are riskier
for mothers and babies. Millions of babies, like Louise Brown,
have been born from IVF and have had normal, healthy lives. The long-term health consequences
of ovarian stimulation with IVF medicines are less clear, though so far, IVF seems safe for women. Because of better genetic testing, delayed childbearing, increased accessibility
and diminishing cost, it’s not inconceivable that artificial
baby making via IVF and related techniques could outpace natural reproduction
in years to come.

How do pregnancy tests work? – Tien Nguyen


The earliest known pregnancy test
dates back to 1350 BC in Ancient Egypt. According to the Egyptians, all you have to do is urinate on wheat
and barley seeds, and wait. If either sprouts,
congratulations, you’re pregnant! And if wheat sprouts faster, it’s a girl,
but if barley, it’s a boy. In 1963, a small study
reproduced this test and found that it predicted pregnancy
with a respectable 70% accuracy, though it couldn’t reliably
tell the sex of the baby. Scientists hypothesized
that the test worked because pregnant women’s urine
contains more estrogen, which can promote seed growth. Now it’s easy to take
this ancient method for granted because modern pregnancy tests give
highly accurate results within minutes. So how do they work? Over-the-counter pregnancy tests
are all designed to detect one thing: a hormone called HCG. HCG is produced in
the earliest stages of pregnancy and starts a game of telephone that tells the body not to shed
the inner lining of the uterus that month. As the pregnancy progresses, HCG supports the formation
of the placenta, which transfers nutrients
from mother to fetus. The test starts when urine is applied
to the exposed end of the strip. As the fluid travels up
the absorbent fibers, it will cross three separate zones,
each with an important task. When the wave hits the first zone,
the reaction zone, Y-shaped proteins called antibodies
will grab onto any HCG. Attached to these antibodies
is a handy enzyme with the ability to turn on dye molecules,
which will be crucial later down the road. Then the urine picks up
all the AB1 enzymes and carries them to the test zone,
which is where the results show up. Secured to this zone are more
Y-shaped antibodies that will also stick to HCG
on one of its five binding sites. Scientists call this type of test
a sandwich assay. If HCG is present, it gets sandwiched
between the AB1 enzyme and AB2, and sticks to the test zone, allowing the attached dye-activating
enzyme to do its job and create a visible pattern. If there’s no HCG, the wave of urine
and enzymes just passes on by. Finally, there’s one last stop to make,
the control zone. As in any good experiment, this step confirms that
the test is working properly. Whether the AB1 enzymes never saw HCG, or they’re extras because Zone 1
is overstocked with them, all the unbound AB1 enzymes picked up
in Zone 1 should end up here and activate more dye. So if no pattern appears,
that indicates that the test was faulty. These tests are pretty reliable,
but they’re not failproof. For instance, false negatives can occur if concentrations of HCG
aren’t high enough for detection. After implantation, HCG levels double
every two to three days, so it may just be too early to tell. And beverages can dilute the urine sample, which is why doctors recommend taking
the test first thing in the morning. On the other hand, false positives
can come from other sources of HCG, like IVF injections, ectopic pregnancies, or certain cancers such as uterine cancer
or testicular cancer, making it possible for one of these tests
to tell a man he’s pregnant. The best way for a woman to find out
for sure is at the doctor’s office. The doctors are also looking for HCG, but with tests that are more sensitive
and quantitative, which means they can determine
the exact level of HCG in your blood. A few minutes can feel like forever when you’re waiting on the results
of a pregnancy test. But in that brief time, you’re witnessing
the power of the scientific method. That one little stick
lets you ask a question, perform a controlled experiment, and then analyze the results
to check your original hypothesis. And the best part is you won’t even
have to wait until the next harvest.

Normal Fetal Movement and Growth | Kaiser Permanente


(lighthearted instrumental music)>>Lissa Daimaru-Enoki, MD OB/GYN
– Prior to 28 weeks,
baby’s movement may not be very predictable, sometimes babies are really active, sometimes they’re resting.>>Eric Warshaw, MD OB/GYN
– As your pregnancy progresses, particularly in the third trimester, you’re going to want to keep a
close eye on fetal movements.>>Fonda Mitchell, MD OB/GYN
– So this is when the fetal movement becomes a little bit more prominent. You’re going to start
to feel full body turns as your baby’s doing somersaults, a little kick, a little punch, those kind of sensations are
going to be more frequent.>>Julia Barnes, MD OB/GYN
– And we sometimes
suggest that you do what we call fetal kick counts. Which is actually where
you’re focusing on your baby’s movements, and getting
used to what’s normal for you and normal for your baby.>>Esther, 20 Weeks Pregnant
– After the baby started kicking, when I didn’t feel the baby kick, it would make me a little bit nervous, but I think I, yeah, I found a lot of reassurance from feeling the baby kick>>Alexa, 29 Weeks Pregnant
– I do feel worrisome sometimes
when the baby is not moving. There are moments when all
of a sudden I’ll feel a lot, and then you know, an hour or two goes by and I don’t feel anything that’s like, is everything okay?>>Kevin Oberbeck, MD OB/GYN
– You often are distracted during the day, and you may not feel
the baby move as often, and if you’re worried about that, lay down in a dark, quiet area, and count.>>Eric Warshaw, MD OB/GYN
– In a two-hour period
you should feel the baby move ten times, if you
haven’t it’s important to contact your doctor,
and it’s very important that you don’t say oh,
I have an appointment the next day, I’ll just follow up then. Any change in the fetal movement, particularly decreased fetal movement, is important to let your provider know.

My Baby is Engaged! What Does that Mean?


My baby is engaged! What does that mean? Last year, it meant wedding bells on the horizon.
Today, it means the baby has moved into the pelvis, and you’re closer to giving birth. The doctor said the baby does not have to
be engaged for me to go into labor. Yes, you can go into labor without the baby
being engaged. But the baby cannot get through the pelvis if it does not get into the pelvis
to begin with. That’s what labor is, pushing through. If the baby is not engaged, you’ll spend
hours more in labor trying to push the kid down and then out. If the kid has already
engaged, labor will be the standard six to sixteen hours, unless he inherited your husband’s
big head. I’ve heard that’s when they get the vacuum
cleaner out. The vacuum is less risk than the forceps,
which could dislocate a kid’s arm or cause brain damage. Or having a C-section. The only thing worse than having really long
labor, is having a C-section afterward. When the baby is engaged, the baby is around
stage zero, plus or minus one. If the kid is not engaged, the nurse says that is a minus
two or minus three station. So I want the baby at this point. You’re way less likely to have a C-section
if he’s engaged, and more likely to have a shorter labor. So I’m about to go into labor. Most babies engage around week 38, and labor
is normally week forty plus or minus two weeks. You could drop the load this evening, or lug
it around another month, but you better hope he doesn’t dis-engage. Does that ever happen? If the mother goes into labor and the kid
has not engaged, you’ll see the labor pause when the kid drops into the pelvis. That’s
when the body rests before the next big push. Or a thousand pushes for that last few inches. This is why they jokingly say you are pushing
a bowling ball through a straw, and why no one jokes when they call it labor. So having the kid engage is a good thing. In utero, yes, and any other time in the next
eighteen years, heck no. There are women doing hula hoops on a birthing ball, and open knee
stretches trying to get their kid in that position. The doctor says the kid is punching the bladder
and kicking the diaphragm, so I do not think it is breech. Then I’m glad I’m in this
position. That’s head down all right. Now get yourself
to bed so you can catch up on sleep, because you won’t get enough for the next six months.

What’s the Deal with Antibiotics and Birth Control?


[ ♪INTRO ] You might have heard that you should use a
back-up method of protection if you’re taking birth control pills and antibiotics at the
same time. You might have even read it on the pill package
itself! And if it’s on the packaging, well, you’d
assume there’s good reason. But… It turns out the majority of reports of this
are inconclusive and anecdotal. In fact, it seems like only one type of antibiotic
is actually worth the extra caution. But when you look closely at how birth control
pills work, it makes sense that doctors would be worried. Oral contraceptives use hormones to prevent
pregnancy. They include estrogens and progestins, or
just progestins alone — though most include some kind of estrogen, because they’re better
at stopping the pituitary gland from releasing the hormones needed for egg development and
preparing the uterus for implantation. Basically, estrogens prevent ovulation really
well. Though, they only work if there are enough
of them in the blood. That’s why the pills have to be taken every
day. But, blood estrogen levels aren’t entirely
dependent on pills, because your body makes some estrogens, and it can recycle them. Like lots of things, estrogens undergo a process
called conjugation in the liver where they’re combined with other molecules — often glucuronic
acid. This creates larger compounds that are secreted
into the intestines in bile. From there, they get excreted in feces — unless
gut bacteria step in. Some bacteria chop off the added bit, thereby
converting these chemicals back into active estrogens, which can get reabsorbed. And research in animal models has suggested
this recycling could be important for ensuring blood estrogen levels are high enough for
effective contraception. That’s where the concern with antibiotics
comes from. You see, in theory, antibiotics could kill
off some or all of the intestinal bacteria involved in this estrogen recycling program
— which could, in theory, make the pills less effective. The thing is, there just isn’t really any
evidence this happens. A 2002 review noted that neither estrogen
nor progestin levels seem to drop when people take antibiotics. And a 2011 study of 1,330 cases of pregnancies
that occurred while people were on birth control found no connection between contraceptive
failure and antibiotic use. Indeed, despite decades of research, a 2018
systematic review failed to find evidence that any of the major classes of antibiotics
interfere with birth control. There is one exception to all of this, though:
Rifampin, an antibiotic primarily used to prevent and treat tuberculosis. It can cause a notable drop in estrogen levels,
and it has been linked to unexpected pregnancies. But here’s the weird part: the way it interferes
with birth control has nothing to do with gut bacteria. You see, your liver manages the levels of
all sorts of hormones and drugs. So it produces a variety of enzymes that break
things down or otherwise prepare them for excretion. And it just so happens that this particular
bacteria-killing compound signals liver cells to ramp up the production of some of these
enzymes. Specifically, rifampin increases the activity
of cytochrome P450s or CYPs, for short. One of the things they’re involved in is
the conjugation of estrogens — they prepare the estrogen molecule for the attachment of
glucuronic acid and other conjugates. So by increasing CYPs, rifampin speeds up
the conjugation of estrogens — and so much so that it leads to increased excretion of
them. Which means its effects may not be limited
to oral contraceptives. Other estrogen-containing birth control methods
like the patch and the ring could be impacted too, but there hasn’t been enough research
to say for sure. And this isn’t just about estrogens. CYPs also seem to be involved in the excretion
of progestins. And rifampin also increases production of
globulin, a protein in your blood that binds circulating progestins and reduces their availability. So it probably interferes with progestin-only
pills, too, though again, more research is needed. In fact, CYPs help your liver deal with a
lot of things, so birth control is just one of many drugs that rifampin interferes with. Still, it’s not used for a lot of infections
— mostly tuberculosis — so the odds are, if you’re taking an antibiotic for anything
else, it’s not going to interfere with your preferred method of contraception. But some still think it’s better to be safe
than sorry, which is why the warnings on basically all antibiotics persist. Thanks for watching this episode of SciShow! If you’re hungry for more information about
antibiotics, might I suggest our video looking at some weird places we might find more of
them. And to have more awesome science videos delivered
right to your YouTube feed, be sure to click that subscribe button and ring the notification
bell! [ ♪OUTRO ]

A DEAL WITH THE UNIVERSE – Trailer – Peccadillo


If all goes to plan this will be the
last holiday we take, just the two of us. This is my partner Tracy and I’m Jason. I bought this video camera because Tracy and I
are about to embark on something really exciting. You’ve got some kind of freaky plan or stupid idea
that you could have a baby! (laughs) It’s 2003. I’ve been on testosterone since 2000.
I’ve had chest surgery. I haven’t got the ZZ Top beard yet but I
think I look pretty fine. We both always imagined ourselves being parents. We went to a clinic and the test said it was unlikely to work with Tracy’s eggs. And then I thought, actually, I have ovaries! I stopped testosterone. My period started again.
And we were off! One… Two… Three… Please! – Will you still love me if it’s negative?
– No! Oh don’t! I thought the universe would love this. Pregnant man? I’ll have some of that! I’m gonna give it a go! I spent a lot of time saying:
“I can do this it’s fine” And a lot of time getting used to
being called ‘She’. Even the doctor referred to me
as ‘She’ a couple of times. – How could it have been more dramatic, Tracy?
– We’re fine! I worry if I have a negative thought, the egg won’t
develop or implant or something like that. I’m breathing energy into my punani. (laughter)

How to Deal with Morning Sickness


How to Deal with Morning Sickness. For some expectant moms, it might as well
be called morning, noon, and night sickness. But there are ways to quell the queasiness. You will need Prenatal vitamins Crackers or
dry cereal Plenty of fluids Bland foods Ginger root or ginger candy Lemons or lemonade Peppermint
tea Salty potato chips Teeth brushing Vitamin B6 (optional) Acupuncturist (optional) and
a hypnotist. Call your doctor if you have a fever, or your
nausea and vomiting persists well beyond your 13th week, and check with them before taking
any medications. Step 1. If you’re trying to get pregnant, start popping
prenatal vitamins now. Some studies indicate they can help prevent
morning sickness if taken at the time of conception. Step 2. Set your alarm clock for a little earlier
than usual so you don’t have to jump out of bed. Nibble on crackers or dry cereal before you
get up. Step 3. Sip fluids throughout the day – but not
with meals. Have a beverage half an hour before and after
you eat. If drinking makes you queasy, try eating foods
with a high water content – like lettuce, melon, and citrus fruits. Step 4. Eat small meals throughout the day so you
don’t get too hungry – or too full. Step 5. If you can’t stand the smell, get out of the
kitchen! Let someone else do the cooking, or turn on
the exhaust fan over the stove to draw out odors. Whoever’s cooking, make sure to prepare bland
foods that don’t smell strong. Step 6. Try remedies that have been found to relieve
nausea: ginger root, ginger candy, lemons, lemonade, and peppermint tea. Just sniffing them can help. Salty chips also calm some stomachs. If you’re vomiting a lot, brush your teeth
more often. You’ll feel better with a fresh mouth, and
you’ll reduce the chances of tooth decay. Step 7. Talk to your doctor. They may suggest vitamin B6, a supplement
that sometimes helps with nausea and vomiting. Step 8. If all else fails, try an alternative route. Acupuncture and hypnotism help some women. Did you know Did you know? Some expectant fathers get morning sickness,
too. It’s a symptom of what’s called “couvade syndrome,”
from a French word meaning “to hatch.”

How To Deliver a Baby At Work


♪ ♪ Hi Depotec employees. By now you’ve learned
the phone system, and how
to fax memos like it’s 1999. [ giggling ]
Your next corporate training video
is about working motherhood. But first, we’re gonna
need some help. Say hi to Amy, one of our
top L.A. office managers. Hi. I’m excited to help out. As you may know,
the United States has
no guaranteed policy of paid maternity leave. But here at Depotec,
we respect working mothers, and also want to
save a little money.
[ chuckles ] Which is why we train
our employees to deliver
one another’s babies. Wow!
What a great company policy. It is. Because remember,
no paid maternity leave means
that a hospital birth counts as break time. Now Amy, why don’t you
hop up on that desk,
and pretend to be in labor. [ grunting, breathing heavily ] [ glass clanks, water splashes ]
Ooh. Sorry. Made it. Now remember employees,
before you help another
employee give birth, you got to make sure they sign the
Infant Consent Liability forms. And moms, please,
try to keep the noise
to a minimum. Some people
have calls to be on. Now let’s talk about
your water breaking. But wait, Dan,
isn’t that unsanitary? It is. So mothers, please do your
best to keep your bodily fluid inside your body
at all times. We’ve got to keep
this office clean. No problem… buddy. Now let’s talk
umbilical cords. Using company property
to cut the umbilical cord
is an absolute no-no. These scissors
are useless now. And remember,
if you’re lucky enough to give
birth in front of Brian from finance, you can thank the
government for the policy that
made that possible. ♪ ♪

Full Interview: Howie Mandel on Returning to ‘Deal or No Deal’


God, I am so embarrassed. Yeah, what a coincidence. I am so embarrassed. It’s good to see that I am a
role model for the children. Yeah. That’s what it is. That’s what it is. That’s what it is. I mean, I am a trendsetter. Yeah. So do you know that this is your
28th appearance on the show? 28! Wow! Wow. I love this show. I love you. I love you. I love everything
about this show. Can I tell you something? And I talked to the
producers before. So I just did Deal or No
Deal, which is coming back. Starts next Monday,
a Christmas special. And we’ll talk about
that a little later. But the stage manager that we
were using on Deal or No deal was a guy named DC. Do you remember DC? Yes. He was a stage manager here. Yes. And one of the reasons
I wanted to come on, besides promoting the show,
is, I think I have an apology. I’m such a guilty person. I have an apology to make. In your second season– I think the producers
pulled a picture. I’ll ask for it
in just a second. In the second season, I was on. You were doing the show in
the park someplace in Burbank. And you had– that’s me and you. And look at my bangs,
they hang me on my lip. And you head on, at that
time– this many years ago. Do you know the show Stomp? Do remember it? I love the show Stomp. I’ve seen it many times. I saw it on Broadway. Stomp is a show where these
dancers, and percussionist, and performers with
garbage cans, and street– they did an amazing, musical,
dance show, which was amazing. And you had them on the
show, but before I had ever seen them. I didn’t know. So let’s show a picture
of them wide on the stage. Show me the picture wide. Because I want to show the– so these people come on stage. And so they’re all– I don’t know this. I was on right before them. So right before them,
DC, the stage manager– I just heard this story–
said, Howie, you’re on now. I was eating a tuna salad
sandwich just before I went on. I was eating a tuna– now, give me the closeup
of this lady, right here. This lady, right here. OK. As I was walking on, I didn’t
know there was a Stomp. I just saw a lady walking
by with a garbage can. This is a tuna salad sandwich. And they had to
do the whole show. So I apologize. I don’t– Stomp. And the lovely– I saw it. I didn’t mean. Stay on one camera. I need to apologize. Where do I apologize. I’m sorry. Next time you see me, you
could stomp on my head. You can do– I feel so bad. That’s my sandwich in your can. That’s your sandwich in my can. That’s what you said. If somebody just tunes in right
now, that’s coming out wrong. You have to look closely. I don’t think anybody
would have seen that. But now we do know that. She knew. And when you listen to it–
they did just a picture. If you listen to it, the tune
is– it’s a little out of tuna. See? Do I have to explain that. I didn’t have to
explain that, one. No, I didn’t have to– they got that one
all on their own. I didn’t have to
explain it at all. Are you working
for the holidays? Or do you ever take time off? Because I know you– I’m getting ready. What I do is family time. I do family– I’ve got grandchildren now. I went and got my
holiday pedicure. I did. Why do you laugh at that? I do. I swear to you. It’s not even a joke. Look! Uh-huh What? Why do you laugh? That’s your holiday– That’s not what I was going for. That’s your holiday pedicure. I go with my granddaughter. And she picks the colors. It’s a grandfather-granddaughter
bonding thing. That’s sweet. It is sweet. And then I– [AH-ING] Thank you. Oh, that’s her. Yes. So she picks the colors. And we get pedicures every week. You know what happened, though? No. This is– I got to tell you,
I’m a germaphobe, right? Yes. And somebody was sitting–
it’s in a public place. I’m surprised you
go get pedicures. I’ll do anything for
that little girl. So I’m sitting there. And the woman next to me
is getting a manicure. And there was a clip. And I heard the clip. And the clip, it
landed on my tummy. There was– it’s not funny. No, this is not funny. Explain why it’s
not funny, for me. Tell them. I had a hard time. There was a clip. And I don’t want to say, ma’am! I’ve got so– I
started panicking. And I had an anxiety attack. And I texted my son. And he had to drive there. And I was just sitting there
with my colored, pedicured feet, going, I can’t get up. Because I didn’t
want to touch it. Yeah. I don’t know if you saw this. I’m on Instagram, @HowieMandel. My daughter took me. I went to a drugstore. And she said, this’ll
be funny, Dad. Put the plunger on your head. So I put it on my head. I put it on Instagram. You could– look, look. But wait, wait, wait. It doesn’t come off. What you don’t see on
Instagram, I had to go buy– I’m not plugging it– but
we bought Nivea cream. I had to, so that
I could slide it. So you could get it off. I had no money with me. I had to go to
the cash register. With that on your head! With that on my head! It’s not a joke! Don’t put a plunger– if you’re bald, don’t put
a plunger on your head. You’re going to take
advice from a man like me. I don’t know how this happened. But I’m so excited. So Deal or No Deal
is coming back? Nobody is more
excited than I am. And all kidding aside, 10
years ago, it changed my life. I think it changed
television, game shows. And I’ve been scratching
and clawing to get it back. And the lovely people at CNBC
were nice enough to buy it. It is bigger, more exciting. And then, before it launches
on CNBC, which is the 5th, this coming Monday, NBC is
doing a big Christmas special. It’s the 26 models, $1 million. There’s some twists. It is so exciting. And I don’t know if it’s because
we’re in a different time, now. But just to watch people
who have to make decisions, and people are screaming,
and men are crying, and people are falling
on their knees. Look at the set! It’s even more beautiful–
well, so am I– than it ever was. All right. And you brought a clip, right? I did. Let me set this up. Because you have
to watch the show. But this is the one
that’s airing Monday, on NBC, the holiday special. I’m just going to give
you a piece of it. And I hope you could feel the
intensity that this show is. So this is a young
man who just got married, doesn’t own a home. He’s a young kid,
him and his wife. He’s playing the game. He has just got offered a
1/4 of $1 million, cash. They said, you could
take the cash right now, and we’ll buy– the banker–
and we’ll buy the case. He says, no deal. Took 1/4 of $1 million. There’s only three
cases left in play. One has 3/4 of $1 million. One has $500. And one has $75. [GROANING] I know! If he’s going to open one more
case, if he opens the $750,000, the most he can go
home with is $500. And he just turned
down 1/4 of $1 million. That’s crazy. Isn’t that amazing? Yes. Watch this! OK. 17, let’s see what you got! Ashley, I can’t
stand up anymore. Ashley, open your case. Come on, Ashley. Come on, believe! Come on, Ashley! Come on! Come on. [GROANING] You’re going to have
to watch, Monday! Oh, no! I mean, well, yeah. That looks very– I loved it when it was on. And I’m telling you, it
is bigger, and better, and more exciting. So we have a big
Christmas special on NBC right after The Voice on
Monday, followed on Wednesday. And it goes into
a series on CNBC. And it’s the same amount of
models, and all that stuff. Well, Chrissy Teigen is
no longer a model on it. She said she was
busy making babies. And Meghan Markle, also. I guess it’s contagious,
making babies. She would have shown up
if she wasn’t pregnant. Now, there’s new models. We have some of the old models. Whoa, there she is. Look how excited she is! Yeah. Do you remember her? No! I don’t! I swear to God,
I have no memory. And I don’t even remember
what number she was. And neither does she. Look at that! There’s no number on the case! Never seen somebody with
a case with no number. It’s very exciting. I’m excited. I can’t wait. But yet, I will. Deal or No Deal returns
on December 5th on CNBC, but by Monday night on NBC. Big special! All right, we’ll be right back.